The discussion of the doctoral thesis, by Ms. Masters / Silvia Azmi Bushra - Teacher Assistant in Department of Biochemistry, Faculty of Pharmacy, Oct 6 University It was held in Saturday, 22 -12 -2012.

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The discussion of the doctoral thesis, by Ms. Masters / Silvia Azmi Bushra - Teacher Assistant in Department of Biochemistry, Faculty of Pharmacy, Oct 6 University It was held in Saturday, 22 -12 -2012. The title of the thesis: “Insulin–like growth factors and some of their binding proteins in Acute Lymphoblastic Leukemic Pediatric Egyptian Patients” Under supervision of: Prof. Dr Atef Tadros Fahim, Prof of Biochemistry and Vice Dean of Faculty of Pharmacy, October 6 University. Prof. Dr. Nadia Iskander Zakhary, Prof. of Medical Biochemistry, National Cancer Institute, Cairo University and Minister of Scientific Research. Prof. Dr. Emad Nabil Ebeid, Prof. of Pediatric Hematology and Oncolog, Pediatric Oncology Department, National Cancer Institute, Cairo University. Ass. Prof. Dr. Maha Mahmoud El-Sawalhi, Ass .Prof. of Biochemistry, Faculty of Pharmacy, Cairo University. The committee of discussion consisted of: Prof. Dr Atef Tadros Fahim, Prof of Biochemistry and Vice Dean of Faculty of Pharmacy, October 6 University. Prof. Dr. Nadia Iskander Zakhary, Prof. of Medical Biochemistry, National Cancer Institute, Cairo University and Minister of Scientific Research. Ass. Prof. Dr. Maha Mahmoud El-Sawalhi, Ass .Prof. of Biochemistry, Faculty of Pharmacy, Cairo University. Ass. Prof. Dr. Maha Mahmoud El-Sawalhi, Ass .Prof. of Biochemistry, Faculty of Pharmacy, Cairo University. Prof. Dr. TareK Mohamad Kamal Motawa, Prof. and Head of Biochemistry Department, Faculty of Pharmacy, Cairo University. Prof Dr. Ahmad Mohamed Salam, Prof. of Biochemistry, Faculty of Pharmacy, Ain Shams University. English Abstract: “Insulin-like growth factors (IGFs) and IGF- binding proteins (IGFBPs) have been reported to play an important role in tumor proliferation. This study aimed to investigate the validity of measuring IGFs and specific IGFBPs in the serum of Egyptian children with acute lymphoblastic leukemia (ALL) as additional markers in diagnosis and follow up of the disease. IGF-I, IGF-II, IGFBP-2 and IGFBP-3 were determined in the sera of 33 ALL patients from the National Cancer Institute at time of diagnosis and after the intensification phase of chemotherapy (IPC) as well as in 15 healthy children, served, as a control group using ELISA technique. These patients were diagnosed by complete blood count and bone marrow aspiration and they also showed high serum lactate dehydrogenase activity at time of diagnosis that decreased after IPC. At time of diagnosis, serum IGF-I, IGF-II and IGFBP-3 were significantly decreased in ALL patients as compared with the control group. After IPC, serum levels of IGF-I and IGF-II increased and returned to their normal levels, while serum IGFBP-3 was significantly increased but its level was still lower than the normal level. On the other hand, serum IGFBP-2 was significantly increased in ALL patients at diagnosis and returned to the normal level after IPC. In conclusion, IGF system could be useful to support diagnosis and follow-up of children with ALL.” This thesis is the result of collaboration between the Department of Biochemistry October 6 University and Cancer Institute, Cairo University. Dr. Silvia Azmi is graduated from the Faculty of Pharmacy, October 6 University (June / 2000) and is considered as the first to earn a doctoral degree in Faculty of Pharmacy October 6 University.